1. Education Background
Tianjin University
Chemical engineering, PhD, School of Chemical Engineering
Tianjin University
Biology, MD, College of Life Sciences
Qufu Normal University
Chemical Engineering and Technology, BD, School of Chemistry and Chemical Engineering
2. Professional Experience
Northwest Agriculture and Forestry University
Associate Professor, School of Food Science and Engineering
Shaanxi Normal University
Associate professor, School of Chemistry and Chemical Engineering
Hong Kong Baptist University
Hong Kong Scholars, Department of Chemistry
3. Research Interests
Dr. Kong Jia, an Associate Professor and recipient of the "Hong Kong Scholar" award from China's Ministry of Human Resources and Social Security, specializes in amyloid protein structural analysis and protein/peptide-based biomaterial engineering. His research program integrates fundamental studies of amyloid fibrillation mechanisms with applied developments in functional biomaterials, driving innovations in food preservation technologies, biopesticide formulations, and sustainable agricultural solutions.
With interdisciplinary expertise spanning structural biology, supramolecular chemistry, and materials science, Dr. Kong has authored nearly 30 articles in journals including Nature Communications, Angewandte Chemie International Edition, and Protein & Cell, alongside co-authoring a professional textbook. His work establishes methodology frameworks for protein analysis and demonstrates translational potential in industrial applications.
4. Representative Publications
30. Kong, J.#; Zhang, J.#; Zhang, Y.#; Xue, H.; Guo, X.; Wang, N.; Gao, Z.; Sun, M.; Xia, Y.; Wang, Y.; Ren, H.; Yang, P.*; Wong, M.S.*. Hydrogen Bond-Driven N-Terminal Amyloid β Mimetics Attenuate Neurotoxic Aggregation. Chem. Mater.2025, 37 (18), 7326-7336.
29. Feng, N.; Zhang, J.; Tian, J.; Zhang, Y.; Li, M.; Guo, X.; Han, Q.: Wang, Y.; Gao, A.; Wang, Y.; Yan, L.*; Kong, J.*; Yang, P.* Preserving Fruit Freshness with Amyloid-Like Protein Coatings. Nat. Commun. 2025, 16(1), 5060.
28. Song Q., Zhang H., Lan Y., Kong J., Wong M.S.*, Li H.W.* Direct and selective nanosensor for amyloid-β oligomers in serum for Alzheimer's disease diagnosis. RSC Adv. 2025, 15(20):16175-16182.
27. Song Q., Zhang H., Kong J., Wong M.S.*, Li H.W.* A turn-on fluorescent immunosensor for neurodegenerative disease related neurofilament light chain protein. Mikrochim Acta. 2025, 192(3):131.
26. Yang Y.; Wang C.; Kong J.; Zhang J.; Wong M. S.* Multifunctional nanoprobe for near-infrared and magnetic resonance dual-modal amyloid-β imaging and oxidative stress monitoring in early stage of Alzheimer's disease, Chem. Eng. J. 2025, 519, 165383.
25. Feng, N.#; Guo, X.#; Chen, M.: Chen, X; Yan, L.*; Yang, P.*; Kong, J.*. Underwater Superpolymphobic Amyloid-Like Protein Coating for Polymer Separation. Sep. Purif. Technol. 2025,132965.
24. Feng, N.#; Wang, K.#; Guo, X.; Kong, J.; Yan, L.*; Yang, P.*; Ren, H*. Development of flexible electronic interlayer material: advancing by protein-based interfacial adhesion. Adv. Eng. Mater. 2025, 202500391.
23. Feng, N.; Miao, S; Guo, X.; Yang, Z.; Yan, L.*; Yang, P.*; Kong, J.*. Amyloid Proteins Adhesive for Slippery Liquid-infused Porous Surfaces, Macromole Rapid Comm. 2024, 46, 2400596.
22. Wang, C.; Luo, X.; Lin, W.; Qi, Y.; Tang, W.; Kong, J.; Huang, J.; Li, Z.*, Epitaxial self-assembly of Bimetallic MOF heterostructure for fluorescent and colorimetric detection of tetracyclines. Dyes and Pigments 2023, 214.
21. Luo, X.; Huang, G.; Bai, C.; Wang, C.; Yu, Y.; Tan, Y.; Tang, C.; Kong, J.; Huang, J.; Li, Z.*, A versatile platform for colorimetric, fluorescence and photothermal multi-mode glyphosate sensing by carbon dots anchoring ferrocene metal-organic framework nanosheet. Journal of Hazardous Materials 2023, 443.
20. Kong, J.; Zhao, S.; Han, X.; Li, W.; Zhang, J.; Wang, Y.; Shen, X.; Xia, Y.*; Li, Z.*, Quantitative Ratiometric Biosensors Based on Fluorescent Ferrocene-Modified Histidine Dipeptide Nanoassemblies. Analytical Chemistry 2023, 95, 5053-5060.
19. Kong, J.; Hu, J.; Li, J.; Zhang, J.; Shen, Y.; Yue, T.; Shen, X.; Wang, Y.; Li, Z.*; Xia, Y.*, Rethreading Design of Ratiometric roGFP2 Mimetic Peptide for Hydrogen Peroxide Sensing. Analytical Chemistry 2023, 95, 8284-8290.
18. Xia, Y.; Hu, J.; Zhao, S.; Tao, L.; Li, Z.; Yue, T.; Kong, J.*, Build-in sensors and analysis algorithms aided smartphone-based sensors for point-of-care tests. Biosensors and Bioelectronics: X 2022, 11, 100195.
17. Luo, X.; Wang, C.; Huang, G.; Tan, Y.; Tang, W.; Kong, J.; Li, Z.*, Bio-inspired chitosan aerogel decorated with MOF-on-COF heterostructure hybrid as recyclable scavenger of herbicides in water. Separation and Purification Technology 2022, 298, 121616.
16. Kong, J.; Li, W.; Zhao, S.; Zhang, J.; Yue, T.; Wang, Y.; Xia, Y.*; Li, Z.*, Color-Tunable Fluorescent Hierarchical Nanoassemblies with Concentration-Encoded Emission. Small 2022, 18, 2201826.
15. Kong, J.; Li, W.; Hu, J.; Zhao, S.; Yue, T.; Li, Z.*; Xia, Y.*, The Safety of Cold-Chain Food in Post-COVID-19 Pandemic: Precaution and Quarantine. Foods 2022, 11, 11111540.
14. Huang, M.; Kong, J.; Zhang, J.; Wang, Z.; Hao, D.; Zhang, J.; Wang, Y.*; Qi, W.*; Su, R.; He, Z., Enhanced Polychromatic Luminescence of Bionic Peptidyl Nanoparticles Driven by Hydrogen Bonds. Particle and Particle Systems Characterization 2022, 39, 202100260.
13. Li, Q.; Yang, X.; Zhang, L.; Wang, Y.*; Kong, J.; Qi, W.*; Liang, Y.; Su, R.; He, Z., Thermally Induced Structural Transition of Peptide Nanofibers into Nanoparticles with Enhanced Fluorescence Properties. ChemPlusChem 2020, 85, 1523-1528.
12. Kong, J.; Zhang, J.; Wang, Y.*; Qi, W.*; Rao, H.; Hu, L.; Su, R.; He, Z., Bioinspired pH-Sensitive Fluorescent Peptidyl Nanoparticles for Cell Imaging. ACS Applied Materials and Interfaces 2020, 12, 4212-4220.
11. Kong, J.; Zhang, J.; Wang, Y.*; Qi, W.*; Huang, M.; Su, R.; He, Z., Bioinspired Fluorescent Peptidyl Nanoparticles with Rainbow Colors. ACS Applied Materials and Interfaces 2020, 12, 31830-31841.
10. Kong, J.; Wang, Y.*; Qi, W.*; Su, R.; He, Z., Enzyme-free visualization of nucleic acids during HIV infection by octopus-like DNA. International Journal of Biological Macromolecules 2020, 150, 122-128.
9. Kong, J.; Wang, Y.*; Qi, W.*; Huang, M.; Su, R.; He, Z., Green fluorescent protein inspired fluorophores. Advances in Colloid and Interface Science 2020, 285, 102286.
8. Kong, J.; Wang, Y.*; Qi, W.*; Su, R.; He, Z., Photo- and Aromatic Stacking-Induced Green Emissive Peptidyl Nanoparticles for Cell Imaging and Monitoring of Nucleic Acid Delivery. ACS Applied Materials and Interfaces 2019, 11, 15401-15410.
7. Kong, J.; Wang, M. M.; He, S. Y.; Peng, X.; Qin, X. H.*, Structural characterization and directed modification of Sus scrofa SAMHD1 reveal the mechanism underlying deoxynucleotide regulation. FEBS Journal 2019, 286, 3844-3857.
6. Kong, J.; Wang, Y.*; Zhang, J.; Qi, W.*; Su, R.; He, Z., Rationally Designed Peptidyl Virus-Like Particles Enable Targeted Delivery of Genetic Cargo. Angewandte Chemie International Edition 2018, 57, 14032-14036.
5. He, S.; Kong, J.; Wang, M.; Mi, L.*; Qin, X.*, Enzymatic Activities of SAMHD1s from Human, Pig, and Chicken. Transactions of Tianjin University 2018, 51, 9-17.
4. Kong, J.; Ma, M.; He, S.; Qin, X.*, Mx oligomer: A novel capsid pattern sensor? Future Microbiology 2016, 11, 1047-1055.
3. Xu, B. #; Kong, J. #; Wang, X.; Wei, W.; Xie, W.*; Yu, X. F.*, Structural insight into the assembly of human anti-HIV dynamin-like protein MxB/Mx2. Biochemical and Biophysical Research Communications 2015, 456, 197-201.
2. Li, Y. #; Kong, J. #; Peng, X.; Hou, W.; Qin, X.*; Yu, X. F.*, Structural insights into the high-efficiency catalytic mechanism of the sterileα-motif/histidine-aspartate domain-containing protein. Journal of Biological Chemistry 2015, 290, 29428-29437.
1. Kong, J. #; Xu, B.#; Wei, W.; Wang, X.; Xie, W.*; Yu, X. F.*, Characterization of the amino-terminal domain of Mx2/MxB-dependent interaction with the HIV-1 capsid. Protein Cell 2014, 5, 954-957.
Awards and Honors
(1) Hong Kong Scholars Award, "A Ratiometric Two-Photon Probe for Reactive Oxygen Species Detection and Monitoring of Oxidative Stress in Alzheimer's Disease", 2024, National Postdoctoral Management Committee & Hong Kong Scholars Association.
(2) First Prize (Faculty Advisor), National Undergraduate Life Sciences Competition, "Redesign of Ultra-Small Ratiometric Fluorescent Peptides via Re-wiring Approach", 2023, National Undergraduate Life Sciences Competition Committee.
(3) Second Prize (Faculty Advisor), National Undergraduate Life Sciences Competition, "Biomimetic Peptide-Based Dynamic Color-Changing Behavior via Assembly-Induced Emission", 2023, National Undergraduate Life Sciences Competition Committee.
(4) Second Prize (Faculty Advisor), National Undergraduate Life Sciences Competition, "Design of Ratiometric Fluorescent Peptides and Their Application in Quantitative Analysis of Peptide-based COVID-19 Vaccines", 2023, National Undergraduate Life Sciences Competition Committee.
(5) Outstanding Presentation Award, National Frontiers in Chemical Engineering Doctoral Forum, "Peptidyl Rainbow Kit: Illumine the World", 2019, National Frontiers in Chemical Engineering Doctoral Forum Organizing Committee.
(6) Outstanding Presentation Award, "Innovation for the Future" IBT Interdisciplinary Integration Postdoctoral Academic Conference & Chinese Academy of Sciences Postdoctoral Symposium, "Peptide Mimetic Modulates Amyloid-β Aggregation and Toxicity", 2025, Ministry of Human Resources and Social Security, Service Center for Scholarly Exchanges and Experts.
(7) Silver Award, 3rd Postdoctoral Innovation and Entrepreneurship Competition, "Development of Ultra-low Energy Smart Cold Chain Preservation Technology for Fruits and Vegetables", 2025, Ministry of Human Resources and Social Security.
