1. Education Background
BSc (Hebei Normal University, 2003)
MSc (Hebei University, 2006)
PhD (Tsinghua University, 2009)
2. Professional Experience
Hebei University, Lecture/Associate Professor (2009-2012)
Shaanxi Normal University, Associate Professor (2012-2015)
Shaanxi Normal University, Professor (2015-)
3. Research Interests
Professor Chenghui Liu's research interests primarily focus on several interconnected and cutting-edge areas within analytical chemistry and biotechnology, aiming to advance the frontiers of life analysis chemistry and contribute to the development of more effective diagnostic and analytical solutions. He is dedicated to nucleic acids analysis, where he explores innovative approaches to detect disease-related nucleic acids (such as DNA and RNA) with high precision. His work has been extended to single particle and single molecule analysis to enable high-precision determination of critical biomarkers that bulk analysis methods cannot provide. He also specializes in digital biosensing, a field that leverages digital signal processing and advanced sensor technologies to create highly sensitive, specific, and quantitative biosensing platforms for applications like disease diagnosis and environmental monitoring. Additionally, Professor Liu engages in nano-biotechnology research, integrating nanomaterials and nanoscale engineering with biological systems to design novel tools and methodologies that enhance the performance of analytical techniques.
4. Representative Publications
·Chao Lei, Wenjiao Fan, Jingjing Shi, Zhaowei Tian, Xinrui Duan*, Chenghui Liu*. Persistent Chemiluminescence-Enabled Digital Bead Counting for Quantifying Attomolar MicroRNAs. Nano Lett., 2025, 25, 5469-5476.
·Xinrui Fei, Cao Lei, Wei Ren, Chenghui Liu*. 'Splice-at-will' Cas12a crRNA Engineering Enabled Direct Quantification of Ultrashort RNAs. Nucleic Acids Res., 2025, 53, gkaf002.
·Chao Lei, Wenjiao Fan, Wei Ren, Xinrui Duan*, Chenghui Liu*. Persistent and Ultrastable Chemiluminescence “Super Enriching” on Single Microbead for Sensing Attomolar Biomarkers. Sci. China Chem., 2025, DOI: 10.1007/s11426-025-2736-7.
·Junyue Sun, Xinrui Fei, Wenjiao Fan*, Wei Ren, Jing Zhang, Chenghui Liu*. DNA Hybridization-Accelerated Programable Immno-Aggregation of microbeads Enabling Mix-and-Read Flow Cytometric Protein Analysis. Anal. Chem., 2025, DOI: 10.1021/acs.analchem.5c01971.
·Xinrong Yan†, Qingyuan Wang†, Peiru Yang†, Yuan Liu, Bin Liu, Tian Wang, Dehui Qiu, Shijiong Wei, Desheng Chen, Jun Zhou,* Chenghui Liu,* and Xiaobo Zhang*. Amplification Bias-Free Sequence-Generic Exponential Amplification Reaction. Anal. Chem., 2025, 97, 2308-2317.
·Yuanyuan Dong, Wei Ren*, Yuanyuan Sun, Xinrui Duan, Chenghui Liu*. Aggregation-Augmented Magnetism of Lanthanide-Doped Nanoparticles and Enabling Magnetic Levitation-Based Exosome Sensing. Adv. Mater., 2024, 36, 2407013.
·Yan Qi*, Junyue Sun, Shan Wang, Wei Ren, and Chenghui Liu*. Mix-and-Read Digital MicroRNA Analysis Based on Flow Cytometric Counting of Target-Clicked Nanobead Dimer. Anal. Chem., 2024, 96, 13734-13741.
·Dailu Jia, Chao Lei, Wei Ren,* Chenghui Liu*. Augmented Fluorescence Signaling on a Single BaTiO3 Microbead Optical Booster toward High-Sensitive Biosensing. Anal. Chem., 2024, 96, 8560-8565.
·Shuang Mu, Zhaowei Tian, Wei Ren*, Chenghui Liu*. Laser-Induced Thermophoretic SERS Enhancement on Paper for Facile Pesticide and Nanoplastic Sensing. Anal. Chem., 2024, 96, 19840-19846.
·Jiahui Zhao, Jingli Yan*, Jing Li, Guoyu Shi, Ming Su, Chenghui Liu*, Guifang Jia*. Selective Ligase-based Sample Processing-Free Discrimination and Detection of Site-Specific DNA 5-Hydroxymethylcytosine. Anal. Chem., 2024, 96, 13285-13290.
5. Awards and Honors
Prof Chegnhui Liu won the First Prize of Hebei Provincial Natural Science Award for the project "Research on Highly Sensitive Molecular Diagnostic Analysis Using Molecular Luminescence Technology" (2010), the Second Prize of Hebei Provincial Natural Science Award for the project "Research on Highly Sensitive and Highly Selective Analysis of Novel Biomarker microRNA" (2018), and the Second Prize of Shaanxi Provincial Natural Science Award for the project "Research on New Principles and New Methods of Highly Sensitive Molecular Diagnosis" (2021).
6. Academic Services
·Director and Deputy Secretary-General
—Shaanxi Chemical Society
·Deputy Director
—Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education)
—Key Laboratory of Analytical Chemistry for Life Science of Shaanxi Province
·Editorial Board Member
—Targets
—ChemistrySelect
