1. Education Background
2006-2013 PhD Dalian Institute of Chemical Physics, Chinese Academy of Sciences (Supervisor: Prof. Can Li)
2002-2006 BS Shaanxi Normal University
2. Professional Experience
2021 to present Prof. School of Chemistry and Chemical Engineering, Shaanxi Normal University
2017-2020 Assoc. Prof. School of Chemistry and Chemical Engineering, Shaanxi Normal University
2015-2017 Postdoc University of Konstanz, Germany Mentor: Prof. Jörg S. Hartig
2013-2015 Postdoc University of Maryland, College Park, US Mentor: Prof. Herman O. Sintim
3. Research Interests
Our research focuses on nucleic acid catalytic chemistry, including:
1. Design of metalloDNAzymes (e.g. G4DNA and i-motif) and study of their enantioselective catalytic properties;
2. Exploration of natural and unnatural catalytic roles of DNA (duplex DNA or single stranded DNA) under specific conditions;
3. Construction of nucleotide- or nucleic acid-based materials in the applications of biomimetic, sensors, optical materials etc.
4. Representative Publications
[1] Changhao Wang,#,* Min Hao,# Qianqian Qi, Jingshuang Dang, Xingchen Dong, Shuting Lv, Ling Xiong, Huanhuan Gao, Guoqing Jia, Yashao Chen*, Jörg S. Hartig, Can Li, Highly efficient cyclic dinucleotide based artificial metalloribozymes for enantioselective Friedel-Crafts reactions in water. Angew. Chem. Int. Ed., 2020, 59, 3444-3449.
[2] Changhao Wang,#,* Qianqian Qi,# Wenying Li, Jingshuang Dang, Min Hao, Shuting Lv, Xingchen Dong, Youkun Gu, Peizhe Wu, Wenyue Zhang, Yashao Chen, Jörg S. Hartig, A Cu(II)-ATP complex efficiently catalyses enantioselective Diels-Alder reactions. Nat. Commun., 2020, 11, 4792.
[3] Xingchen Dong, Shuting Lv, Qianqian Qi, Youkun Gu, Peizhe Wu, Wenyue Zhang, Zhuolin Zhang, Libing Yang, Jiaqi Li, Yashao Chen, Changhao Wang*, Cyclic dinucleotide-based enantioselective fluorination in water. J. Org. Chem., 2023, 88, 189-197.
[4] 秦玮骏,# 王梓潇,# 董星辰, 王照辉, 陈亚芍, 王长号*, 核酸不对称催化研究进展. 中国科学：化学, 2024, 54, 1727-1743.
[5] Xingchen Dong,# Ziyang Qiu,# Zixiao Wang, Jiaqi Li, Weijun Qin, Jingshuang Dang, Wenqin Zhou, Guoqing Jia, Yashao Chen, Changhao Wang*, Efficient silver(I)-containing i-motif DNA hybrid catalyst for enantioselective Diels–Alder reactions. Angew. Chem. Int. Ed., 2024, 63, e202407838.
